Lupeol: An Ubiquitous Compound for Multiple Ailments
نویسنده
چکیده
Triterpenoid There is a growing interest in natural triterpenoids, also know as phytosterols, due to their wide spectrum of biological activities [1] . Triterpenes are a wide-spread group of natural compounds with considerable practical significance which are produced by arrangement of squalene epoxide in a chair-chair, chai-boat arrangement followed by condensation. Triterpense are important structural components of plant membranes, and free triterpense severe to stabilize bilayers in plant cell membranes just as cholesterol dose in animal cell membrane.[2]
منابع مشابه
Phytochemical investigations on chemical constituents of Achillea tenuifolia Lam.
Achillea tenuifolia Lam (Asteraceae) afforded a methanolic extract from which after fractionation in solvents with different polarities two known flavones 3’, 5- dihydroxy- 4’, 6, 7- trimethoxy flavone (eupatorine, compound 3), 5- hydroxy- 3’, 4’, 6, 7- tetramethoxyflavone (compound 4), besides stearic acid (compound 1 ), lupeol (compound 2), daucosterol (β- sitosterol 3-O- β- D- glucopyranosid...
متن کاملPhytochemical investigations on chemical constituents of Achillea tenuifolia Lam.
Achillea tenuifolia Lam (Asteraceae) afforded a methanolic extract from which after fractionation in solvents with different polarities two known flavones 3’, 5- dihydroxy- 4’, 6, 7- trimethoxy flavone (eupatorine, compound 3), 5- hydroxy- 3’, 4’, 6, 7- tetramethoxyflavone (compound 4), besides stearic acid (compound 1 ), lupeol (compound 2), daucosterol (β- sitosterol 3-O- β- D- glucopyranosid...
متن کاملIsolation of Lupeol, Design and Synthesis of Lupeol Derivatives and their Biological Activity
The triterpenoid, lupeol (1) has been isolated from the leaves extract of Walsura trifoliate. Few novel derivatives (4a–j) were synthesized from the naturally occurring lupeol (1) and confirmed by spectroscopic methods, and tested for antimicrobial and anti-proliferative activity against MDAMB231, IMR32and A549 cell lines. This all compound showed moderate activities.
متن کاملPlatonia insignis Mart., a Brazilian Amazonian Plant: The Stem Barks Extract and Its Main Constituent Lupeol Exert Antileishmanial Effects Involving Macrophages Activation
Platonia insignis Mart., popularly known as "bacurizeiro," is used in traditional medical practices based on its diverse biological properties. This study was aimed at evaluating the antileishmanial effects of the ethanol extract (EtOH-Ext), hexane fraction (Hex-F), and its main isolated Lupeol obtained from stem barks of P. insignis against Leishmania (Leishmania) amazonensis, as well as their...
متن کاملLupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway.
Pancreatic cancer is an exceptionally aggressive disease, the treatment of which has largely been unsuccessful due to higher resistance offered by pancreatic cancer cells to conventional approaches such as surgery, radiation and/or chemotherapy. The aberration of Ras oncoprotein has been linked to the induction of multiple signaling pathways and to the resistance offered by pancreatic cancer ce...
متن کامل